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7. 0 Conclusions and Guidance to Laboratories, Permittees, And Regulatory Authorities

By Environmental Protection Agency

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Book Id: WPLBN0000010734
Format Type: PDF eBook
File Size: 0.1 MB
Reproduction Date: 2007
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Title: 7. 0 Conclusions and Guidance to Laboratories, Permittees, And Regulatory Authorities  
Author: Environmental Protection Agency
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Publication Date:
Publisher: United States Environmental Protection Agency


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Agency, E. P. (n.d.). 7. 0 Conclusions and Guidance to Laboratories, Permittees, And Regulatory Authorities. Retrieved from

Excerpt: This document was prepared to address whole effluent toxicity (WET) test variability. The document has three goals: (1) quantify the variability of promulgated test methods and report a coefficient of variation (CV) as a measure of test method variability; (2) evaluate the statistical methods described in the TSD for determining the need for and deriving WET permit conditions; and (3) suggest guidance for regulatory authorities on approaches to address and minimize test method variability. This document quantified the variability of toxicity test methods based on the end use of the data, that is, the effect concentrations (e.g., NOEC, LC50, EC25). The within-laboratory variability of these effect concentrations was quantified by obtaining multiple test results under similar test conditions using the same reference toxicant. The major conclusions of this document are discussed below.

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